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  2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Lesopitron dihydrochloride

Lesopitron dihydrochloride  (Synonyms: E4424)

目錄號: HY-101609 純度: ≥98.0%
COA 產(chǎn)品使用指南

Lesopitron dihydrochloride 是選擇性的 5-HT1A 受體激動劑，作用于大鼠海馬膜，IC50 為 125 nM。

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Lesopitron dihydrochloride Chemical Structure

Lesopitron dihydrochloride Chemical Structure

CAS No. : 132449-89-9

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2000
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Other Forms of Lesopitron dihydrochloride:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.

IC50 & Target

5-HT1A Receptor

125 nM (IC50, in rat hippocampal membranes)

體外研究
(In Vitro)

In vitro binding and autoradiographic studies with [3H]8-OH-DPAT and [3H]Lesopitron as radioligands confirm that Lesopitron binds to 5-HT1A receptors in the rat brain with a relatively high affinity (pKi=7.35). As expected of a full agonist at postsynaptic 5-HT1A receptors, Lesopitron (IC50=125 nM) inhibits forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes to the same extent as 5-HT. Lesopitron inhibits the firing of serotoninergic neurons both in vitro (in brainstem slices, IC50=120 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Lesopitron inhibits the firing of serotoninergic neurons both in vivo (in chloral hydrate-anaesthetized rats, ID50=35 μg/kg i.v.)[1]. Lesopitron administered at a dose which induces anxiolytic behaviour in rats (30 μg/kg, i.p.) markedly reduces 5-HT levels (to 45% of the basal value) in cortical perfusates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

393.74

Formula

C15H23Cl3N6
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

來索吡瓊二鹽酸鹽
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻
Animal Administration
[2]

Rats[2]
Male Wistar rats weighing 270-300 g, are used. Lesopitron is administered either through the dialysis probe (dissolved in artificial CSF) or i.p. (dissolved in 0.9% saline, 2 mL/kg body weight).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

Lesopitron dihydrochloride 相關分類

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Lesopitron dihydrochloride
目錄號：
HY-101609
需求量：