human Rec1 cells |
Function assay |
2.5 μM |
6 h |
Inhibition of Lyn phosphorylation in human Rec1 cells at 2.5 uM incubated for 6 hrs by Western blotting method |
25222877 |
human Ramos cells |
Function assay |
|
1 h |
Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysis, IC50=14 nM. |
24915291 |
Sf9 cells |
Function assay |
|
1 h |
Inhibition of LYN-A expressed in Sf9 cells after 60 mins by TR-FRET Assay, IC50=0.2 μM. |
21958547 |
human DOHH2 cells |
Cytotoxic?assay |
|
72 h |
Cytotoxicity against human DOHH2 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay, IC50=0.41 μM. |
24915291 |
human SU-DHL6 cells |
Cytotoxic?assay |
|
72 h |
Cytotoxicity against human SU-DHL6 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay, IC50=0.58 μM. |
24915291 |
human WSU-NHL cells |
Cytotoxic?assay |
|
72 h |
Cytotoxicity against human WSU-NHL cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay, IC50=1.09 μM |
24915291 |
human Pfeiffer cells |
Function assay |
|
72 h |
Cytotoxicity against human Pfeiffer cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay, IC50=2 nM. |
24915291 |
Sf9 cells |
Function assay |
|
1 h |
Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET Assay, IC50=0.5 nM. |
21958547 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.0003 μM |
29146136 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.00034 μM |
27912175 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.00034 μM |
28432946 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.00034 μM |
27956037 |
Sf9 cells |
Function assay |
|
60 mins |
IC50 = 0.0004 μM |
30006143 |
Sf9 cells |
Function assay |
|
60 mins |
IC50 = 0.0005 μM |
21958547 |
Ramos cells |
Function assay |
|
1 h |
IC50 = 0.0005 μM |
28280261 |
Sf9 cells |
Function assay |
|
60 mins |
IC50 = 0.001 μM |
30077608 |
Pfeiffer cells |
Cytotoxicity assay |
|
72 h |
GI50 = 0.002 μM |
24915291 |
B cells |
Function assay |
|
1 h |
IC50 = 0.0046 μM |
30290988 |
Sf9 insect cells |
Function assay |
|
2 to 60 mins |
Ki = 0.0048 μM |
28315597 |
Ramos cells |
Function assay |
|
1 h |
IC50 = 0.0075 μM |
24915291 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.008 μM |
28315597 |
TMD8 cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 0.01 μM |
29715023 |
CD19+ B cells |
Function assay |
|
1 h |
IC50 = 0.012 μM |
29457982 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.012 μM |
28315597 |
Ramos cells |
Function assay |
|
1 h |
IC50 = 0.014 μM |
24915291 |
Sf9 insect cells |
Function assay |
|
1 h |
IC50 = 0.0144 μM |
29715023 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.0161 μM |
29146136 |
HCC827 cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 0.039 μM |
28734581 |
PC9 cells |
Function assay |
|
72 h |
GI50 = 0.05 μM |
28282122 |
Sf9 cells |
Function assay |
|
60 mins |
IC50 = 0.1 μM |
30006143 |
H3255 cells |
Function assay |
|
72 h |
GI50 = 0.11 μM |
28282122 |
BaF3 cells |
Function assay |
|
72 h |
GI50 = 0.12 μM |
26630553 |
BAF3 cells |
Antiproliferative activity assay |
|
72 h |
GI50 = 0.12 μM |
28956923 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.123 μM |
28315597 |
Sf9 insect cells |
Function assay |
|
60 mins |
IC50 = 0.146 μM |
28315597 |
BAF3 cells |
Function assay |
|
72 h |
GI50 = 0.16 μM |
28282122 |
Sf9 cells |
Function assay |
|
60 mins |
IC50 = 0.2 μM |
21958547 |
MV4-11 cells |
Antiproliferative activity assay |
|
72 h |
GI50 = 0.33 μM |
26630553 |
MV4-11 cells |
Antiproliferative activity assay |
|
72 h |
GI50 = 0.33 μM |
28956923 |
DOHH2 cells |
Cytotoxicity assay |
|
72 h |
GI50 = 0.41 μM |
24915291 |
HCC827 cells |
Antiproliferative activity assay |
|
96 h |
EC50 = 0.45 μM |
28853575 |
SU-DHL6 cells |
Cytotoxicity assay |
|
72 h |
GI50 = 0.58 μM |
24915291 |
NCI-H1975 cells |
Antiproliferative activity assay |
|
96 h |
EC50 = 0.64 μM |
28853575 |
HEK293T cells |
Function assay |
|
1 h |
IC50 = 0.9 μM |
28280261 |
Ramos cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 0.92 μM |
29715023 |
BA/F3 cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 1 μM |
26258521 |
WSU-NHL cells |
Cytotoxicity assay |
|
72 h |
GI50 = 1.09 μM |
24915291 |
NCI-H1975 cells |
Function assay |
|
72 h |
GI50 = 1.2 μM |
28282122 |
NCI-H1975 cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 1.27 μM |
28734581 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 1.49 μM |
29567295 |
A431 cells |
Antiproliferative activity assay |
|
96 h |
EC50 = 2.38 μM |
28853575 |
BAF3 cells |
Antiproliferative activity assay |
|
72 h |
GI50 = 2.5 μM |
28956923 |
Ramos cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 5.14 μM |
30006143 |
Ramos cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 5.14 μM |
27956037 |
Ramos cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 5.88 μM |
28432946 |
Ramos cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 6.62 μM |
29146136 |
K562 cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 7.5 μM |
30077608 |
HL60 cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 8 μM |
30077608 |
Ramos cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 8.11 μM |
27994736 |
Ramos cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 8.26 μM |
29567295 |
BAF3 cells |
Cytotoxicity assay |
|
72 h |
GI50 = 10 μM |
26630553 |
BAF3 cells |
Antiproliferative activity assay |
|
72 h |
GI50 = 10 μM |
28956923 |
BAF3 cells |
Growth inhibition assay |
|
72 h |
GI50 = 10 μM |
28282122 |
NAMALWA cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 10.45 μM |
29146136 |
Ramos cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 12.6 μM |
27912175 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 14.2 μM |
30077608 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 15.2 μM |
27994736 |
MIAPaCa2 cells |
Cytotoxicity assay |
|
3 days |
IC50 = 16.6 μM |
27077228 |
HeLa cells |
Cytotoxicity assay |
|
3 days |
IC50 = 16.8 μM |
27077228 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 19.3 μM |
27912175 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 19.3 μM |
28432946 |
Raji cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 19.5 μM |
30006143 |
Raji cells |
Antiproliferative activity assay |
|
48 h |
IC50 = 19.5 μM |
27956037 |
NAMALWA cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 19.6 μM |
30006143 |
A2780 cells |
Cytotoxicity assay |
|
3 days |
EC50 = 20.1 μM |
27077228 |
Raji cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 20.88 μM |
29146136 |
A549 cells |
Antiproliferative activity assay |
|
72 h |
IC50 = 21.79 μM |
28734581 |
SW480 cells |
Cytotoxicity assay |
|
3 days |
IC50 = 25.6 μM |
27077228 |
Ramos cells |
Cytotoxicity assay |
|
24 h |
IC50 = 28.7 μM |
28274675 |
sf9 cells |
Function assay |
|
|
IC50 = 0.0003 μM |
27994736 |
MV411 cells |
Growth inhibition assay |
|
|
GI50 = 0.25 μM |
28315597 |
M07e cells |
Growth inhibition assay |
|
|
GI50 = 0.59 μM |
28315597 |
SU-DHL-2 cells |
Growth inhibition assay |
|
|
GI50 = 0.64 μM |
28315597 |
Pfeiffer cells |
Growth inhibition assay |
|
|
GI50 = 1.6 μM |
28315597 |
U937 cells |
Growth inhibition assay |
|
|
GI50 = 2.9 μM |
28315597 |
NB4 cells |
Growth inhibition assay |
|
|
GI50 = 3 μM |
28315597 |
Ramos cells |
Growth inhibition assay |
|
|
GI50 = 3.4 μM |
28315597 |
SKM1 cells |
Growth inhibition assay |
|
|
GI50 = 3.6 μM |
28315597 |
U2932 cells |
Growth inhibition assay |
|
|
GI50 = 4.4 μM |
28315597 |
OCI-AML3 cells |
Growth inhibition assay |
|
|
GI50 = 9.2 μM |
28315597 |