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BMS309403

BMS309403是FABP4小分子抑制劑，Kd值為4 nM，對(duì)FABP4的選擇性比對(duì)FABP5和FABP3高100倍以上。

BMS309403 Chemical Structure

BMS309403 Chemical Structure

CAS: 300657-03-8

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買數(shù)量
10mM (1mL in DMSO) 958.23 現(xiàn)貨
5mg 794.93 現(xiàn)貨
25mg 2596.89 現(xiàn)貨
100mg 6306.75 現(xiàn)貨
1g 31695.38 現(xiàn)貨
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BMS309403相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
THP1 Function assay 25 uM 3 days Reduction of transformation of human THP1 cells to foam cells at 25 uM after 3 days relative to control 17554340
aP2+/+ macrophage cells Function assay 25 uM Reduction in total cholesterol ester content in mouse aP2+/+ macrophage cells at 25 uM relative to control 17554340
aP2-/-R macrophage cells Function assay 25 uM Reduction in total cholesterol ester content in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in APOA1-mediated cholesterol in human THP1 cells at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in ABCA1 mRNA level in human THP1 cells at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in ABCA1 protein level in human THP1 cells at 25 uM relative to control 17554340
aP2+/+ macrophage cells Function assay 25 uM Increase in cholesterol efflux in mouse aP2+/+ macrophage cells at 25 uM relative to control 17554340
aP2-/-R macrophage cells Function assay 25 uM Increase in cholesterol efflux in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control 17554340
aP2+/+ macrophage cells Function assay 24 hrs Decrease in MCP1 production in mouse aP2+/+ macrophage cells after 24 hrs 17554340
aP2-/-R macrophage cells Function assay 24 hrs Decrease in MCP1 production in mouse aP2-/-R macrophage cells (re-expression of aP2) after 24 hrs 17554340
BL21(DE3) Function assay Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay, Ki=0.22μM 27460668
BL21(DE3) Function assay Direct binding to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry, Kd=2.05μM 27460668
THP1 Function assay Reduction of Mcp1 expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of Mcp1 expression mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of Mcp1 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of IL1-beta expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of IL1-beta expressed in mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of IL1-beta expressed in mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of IL6 expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of IL6 expression mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of IL6 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of TNF expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of TNF expression in mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of TNF expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
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生物活性

產(chǎn)品描述 BMS309403是FABP4小分子抑制劑，Kd值為4 nM，對(duì)FABP4的選擇性比對(duì)FABP5和FABP3高100倍以上。
靶點(diǎn)
FABP4 [1]
(Cell-free assay)
4 nM(Kd)

化學(xué)信息&溶解度

分子量 474.55 分子式

C31H26N2O3
CAS號(hào) 300657-03-8 SDF --
Smiles CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5
儲(chǔ)存條件(自收到貨起) 3年 -20°C 粉狀

體外溶解度
批次：

DMSO : 95 mg/mL ( (200.18 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Ethanol : 18 mg/mL (37.93 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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