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IOX2

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1921

CAS [931398-72-0]

MF C19H16N2O5
MW 352.34

Purity: 100%
Soluble in DMSO

IOX2

Description

A selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20μM)

YM Tian et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J. Biol. Chem. 2011, 286(15), 13041-13051.

JK Murray et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J. Comb. Chem. 2010, 12(5), 676-686.

Angiogenesis Cell Signaling & Oncology Epigenetics PHD (HIF) Transcription Factors EC 1.14.11.29

Inhibitor of Hypoxia Inducible Factor PHD

Chemical name

2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

Parent CAS No.

[931398-72-0]

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5 mg	€95.00	In Stock
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