Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling.

KEYWORDS: Locostatin | supplier | RKIP/Raf inhibitor | UIC 1005 | UIC1005 | (N-crotonyl)-(4S)-isopropyl-2-oxazolidinone | (S)-(+)-4-benzyl-3-crotonyl-2-oxazolidinone | CAS [90719-30-5] | MAPK | MEK | RAF | Inhibitor | PEBP1 | Phosphatidylethanolamine Binding Protein | cell sheet migration | NF-kB | NIK | PKC | GPCR kinase 2