MLN4924 - Pevonedistat

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2038

CAS [905579-51-3]

MF C21H25N5O4S
MW 443.52

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

MLN4924

Description

First-in-class inhibitor of NEDD8 Activating Enzyme (NAE) with potent antitumor activity in animal models; cell permeable; MLN4924 inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation

TA Soucy et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009, 458, 732-736.

TA Soucy et al. Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer. Clin. Cancer Res. 2009, 15, 3912.

Y Zhao et al. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death and Disease 2012, 3, e386.

JL Toth et al. A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. Cell Reports, 2012, 1(4), 309-316.

Cell Cycle Regulation Cell Signaling & Oncology CNS Ubiquitin EC 6.2.1 Ubiquitin Ligase (E1)

Inhibitor of NEDD8 Activating Enzyme (NAE)

Chemical name

((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate

Parent CAS No.

[905579-51-3]

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Size	Unit Price	Stock
1 mg	€60.00	In Stock
5 mg	€120.00	In Stock
25 mg	€420.00	In Stock

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2 x 5 mg	€180.00	In Stock

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天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

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MLN4924 - Pevonedistat

Description

Chemical name

Parent CAS No.

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