AZD7762 hydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1399

CAS [1246094-78-9]

MF C17H19FN4O2S.HCl
MW 398.88

Purity: 99%
Optical purity: >98% ee
Soluble in water and DMSO

AZD7762 hydrochloride

Description

Potent and selective inhibitor of checkpoint kinase (CHK; IC50 values 5 nM for Chk1/Chk2).

KEYWORDS: AZD7762 hydrochloride | supplier | CHK inhibitor | AZD 7762 | AZD-7762 | CAS [860352-01-8] - [1246094-78-9] | DNA-RNA | checkpoint kinase | CHK1 | CHK2 | stem cell | hematopoetic | HCS

JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.

S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.

SD Zabludoff et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966.

L Carrassa et al. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722.

List of publications using AZD 7762 (Axon 1399) purchased from Axon Medchem

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell p53-Tumor Suppression DNA-damage Response EC 2.7.11.1 CHK

CHK inhibitor

Chemical name

5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3-ylamide hydrochloride

Parent CAS No.

[860352-01-8]

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2 mg	€60.00	In Stock
5 mg	€80.00	In Stock
25 mg	€280.00	In Stock

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Size	Unit Price	Stock
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2 x 25 mg	€440.00	In Stock

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天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

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AZD7762 hydrochloride

Description

Chemical name

Parent CAS No.

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