VX 680 - MK 0457 | Tozasertib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1540

CAS [639089-54-6]

MF C23H28N8OS
MW 464.59

Purity: 98%
Soluble in DMSO

VX 680

Description

Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases

EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 10, 262 - 267 (2004)

GM Cheetham et al. Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett. 2007, 251, 323-329.

FJ Giles et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007, 109, 500-502.

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora

Aurora inhibitor (non-specific)

Chemical name

Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide

Parent CAS No.

[639089-54-6]

Order

Size	Unit Price	Stock
10 mg	€60.00	In Stock
50 mg	€95.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1541	ZM 447439	Aurora B inhibitor	€85.00
1580	AZD1152-HQPA	Aurora B inhibitor	€70.00
1597	Aurora A inhibitor I	Aurora A inhibitor	€125.00
1630	Aurora A inhibitor II	Aurora A inhibitor	€125.00
1783	AMG 900	Aurora inhibitor (non-specific)	€110.00
1836	CCT 137690	Aurora inhibitor (non-specific)	€115.00
1961	MK 5108	Inhibitor of Aurora A kinase	€110.00
2003	MLN8237	Second generation selective Aurora A inhibitor	€90.00
2023	PF 03814735	ATP-competitive inhibitor of aurora kinase A and B	€120.00
2096	Hesperadin	Reversible and ATP-competitive inhibitor of Aurora B	€95.00
2219	AT 9283	Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl)	€85.00
2570	FG-2216	Orally active HIF-PHD inhibitor that increases plasma EPO levels in vivo	€80.00
2474	SPL-B	Inhibitor of TACC3 that inhibits nucleation of centrosome microtubules	€125.00
2906	SNS 314 mesylate	Potent and selective Aurora inhibitor (non-specific)	€90.00
3408	AKI603	Inhibitor of Aurora A kinase	€145.00
3758	LY-3295668	Orally available, potent and highly selective Aurora A kinase (AurA) inhibitor	Inquire
3920	GSK1070916	Potent, selective and ATP competitive inhibitor of Aurora B and C kinases	€110.00
3973	XL-228	Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC)	Inquire
4073	CYC-116	Aurora kinases A & B and VEGFR2 inhibitor	Inquire

天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Customer Support

Customer Services

About Axon Medchem

Contact Us

VX 680 - MK 0457 | Tozasertib

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Customer Support

Customer Services

About Axon Medchem

Contact Us

VX 680 - MK 0457 | Tozasertib

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us