Non-competitive inhibitor of MAGL (monoacylglycerol lipase; IC50 values 25 μM and 17 μM for inhibition of hydrolysis of 2-oleoylglycerol (2-OG) and anandamide (AEA), respectively), lacking affinity for FAAH, diacylglycerol lipase or COX-2. URB602 blocks 2-AG hydrolysis in rat brain slices and enhances non-opioid stress-induced analgesia. Furthermore, URB602 reduced xenograft tumor volume, this effect being associated to down-regulation of VEGF and FGF-2, reduction in the number of vessels and down-regulation of cyclin D1.

KEYWORDS: URB602 | supplier | MAGL inhibitor | URB 602 | URB-602 | CAS [565460-15-3] |  2-arachidonoyl glycerol (2-AG) | MAGL | Inhibitor | Enzymes