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Tienilic Acid - Ticrynafan

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1564

CAS [40180-04-9]

MF C13H8Cl2O4S
MW 331.17

Purity: 99%
Soluble in DMSO

Tienilic Acid

Description

Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. It is a good mechanism based inhibitor of CYP2C9 and seems to inactivate it stoichiometrically

JW Manier et al. Hepatotoxicity associated with ticrynafen – a uricosuric diuretic. Am. J. Gastroenterol. 1982, 77(6), 401–4.

P Jean et al. Oxidation of tienilic acid by human yeast-expressed cytochromes P450 2C8, 2C9, 2C18 and 2C19: Evidence that this drug is a mechanism-based inhibitor specific of cytochrome P450 2C9. Eur. J. Biochem. 1996, 241 797-804.

Diabetes & Metabolism Miscellaneous EC 1.14.13.80 Cytochrome P450

CYP2C10 Inhibitor

Chemical name

[2,3-Dichloro-4-(thiophene-2-carbonyl)-phenoxyl]-acetic acid

Parent CAS No.

[40180-04-9]

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天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

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