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Axon 2853
CAS [152946-68-4]
MF C14H12N4OS.2HClMW 357.26
Nolatrexed dihydrochloride is a water soluble, lipophilic inhibitor of thymidylate synthase (Ki value of 11 nM). Nolatrexed dihydrochloride displayed non-competitive inhibition kinetics and was shown to inhibit cell growth in a panel of cell lines of murine and human origin (IC50 values between 0.39 and 6.6 µM).
KEYWORDS: Nolatrexed dihydrochloride | supplier | Thymidylate synthase inhibitor | AG 337 | Thymitaq | AG337 | AG-337 | CAS [152946-68-4] | [147149-76-6] | Deoxyuridine monophosphate (dUMP) | TYMS | Inhibitor | Enzymes
2-Amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one dihydrochloride
[147149-76-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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