ML 210 - CID 49766530

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2017

CAS [1360705-96-9]

MF C22H20Cl2N4O4
MW 475.32

Purity: 100%
Soluble in DMSO

ML 210

Description

Chemical probe that selectively kills cells induced to express mutant RAS; more specifically, ML210 is a HRAS synthetic lethal compound with nanomolar potencies against two HRASG12V expressing cell lines and 4-fold selectivity against two control cell lines not expressing HRASG12V

JA Bittker et al. Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2. Probe Reports NIH Mol. Lib. Program. PMID: 22834036.

M Weïwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 2012, 22(4), 1822-1826.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK EC 3.6.5.2 HRAS

Chemical probe that selectively kills cells induced to express mutant RAS

Chemical name

(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone

Parent CAS No.

[1360705-96-9]

Order

Size	Unit Price	Stock
10 mg	€115.00	In Stock
50 mg	€415.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1578	NSC 23766	Rac1 inhibitor	€110.00
1639	YM155	Survivin suppressant	€95.00
1825	Erastin	VDAC2 modulator	€90.00
1828	BH3I 1	Inhibitor of Bcl-2 family protein	€125.00
1985	Xevinapant	Antagonist of Inhibitor of apoptosis proteins (IAPs)	€145.00
2141	ABT 199	Potent, orally bioavailable BCL-2-selective inhibitor	€70.00
2165	S 12	Survivin inhibitor	€105.00
2007	HA 14-1	Bcl-2 inhibitor and apoptosis inducer of tumor cells	€75.00
2284	Deltarasin trihydrochloride	Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.	€120.00
2300	Dordaviprone	Small molecule that transcriptionally induces TRAIL	€120.00
2302	Kobe 0065	HRAS inhibitor	€70.00
2184	CID 1067700	First inhibitor of Rab7 GTPase	€125.00
2185	BAM 7	Selective small-molecule activator of proapoptotic BAX	€90.00
2293	Ferrostatin 1	Potent inhibitor of erastin-induced ferroptosis	€85.00
2351	EHop 016	Rac GTPase inhibitor specific for Rac1 and Rac3	€85.00
2396	RBC 8	Inhibitor of the RAS-like small GTPases RalA and RalB	€105.00
2397	BQU 57	Inhibitor of the RAS-like small GTPases RalA and RalB	€125.00
2438	Cuspin-1	Upregulator of the Survival of Motor Neuron protein (SMN) by Ras signaling activation	€95.00
2611	APS-2-79	Inhibitor of KSR and oncogenic Ras signaling	€90.00
2829	Fendiline hydrochloride	KRAS inhibitor; Ca2+ channel blocker (L-type voltage gated)	€50.00
3714	BCL-201 dihydrochloride	BH3-mimetic inhibitor of BCL-2 protein	Inquire
3814	AZD4320	BH3-mimetic inhibitor of BCL-2 protein	Inquire
3821	ABT-263	Potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins	Inquire

天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Customer Support

Customer Services

About Axon Medchem

Contact Us

ML 210 - CID 49766530

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Customer Support

Customer Services

About Axon Medchem

Contact Us

ML 210 - CID 49766530

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us