99% purity available from supplier Axon Medchem, prime source of life science reagents for your research" />

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PKI 587 - PF 05212384 | Gedatolisib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1807

CAS [1197160-78-3]

MF C32H41N9O4
MW 615.73

  • Purity: 99%
  • Moderately soluble in DMSO

PKI 587

Description

Highly potent PI3K/mTOR kinase inhibitor; PKI-587 inhibits PI3K-α, β, γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. PKI-587 inhibits mTOR TOC1 kinase activity in human MDA-MB-361 cells assessed as surppression of 4EBP1 phosphorylation at <30 nM; PKI-587 inhibits Akt S473 phosphorylation in human MDA-MB-361 cells and Akt T308 phosphorylation in human MDA-MB-361 cells with IC50 of 8nM and 10 nM
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Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €270.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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