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Exemestane - Aromasin | FCE 24304

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2045

CAS [107868-30-4]

MF C20H24O2
MW 296.40

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO and Ethanol

Exemestane

Description

Orally active, irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; breast cancer therapy.

D Giudici et al. 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitor. J. Steroid Biochem. 1988, 30 (1–6), 391–394.

N Mauras et al. Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males. J. Clin. Endocrinol. Metab. 2003, 88(12), 5951–5956.

RC Coombes et al. A Randomized Trial of Exemestane after Two to Three Years of Tamoxifen Therapy in Postmenopausal Women with Primary Breast Cancer. N. Engl. J. Med. 2004, 350, 1081-1092.

Cell Signaling & Oncology Endocrinology EC 1.14.14.1 Cytochrome P450

Irreversible steroidal aromatase (CYP19A1) inhibitor

Chemical name

(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

Parent CAS No.

[107868-30-4]

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