ML-9 hydrochloride

Based on 219 reference(s) in Google Scholar 8 10 219

Axon 3343

CAS [105637-50-1]

MF C15H17ClN2O2S.HCl
MW 361.29

Purity: 99%
Soluble in water and DMSO

ML-9 hydrochloride

Description

ML-9 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK). Moreover, ML-9 hydrochloride is an inhibitor of Akt kinase and stromal interaction molecule 1 (STIM1).

M Ito et al. Inhibition of natural killer cell-mediated cytotoxicity by ML-9, a selective inhibitor of myosin light chain kinase. Int J Immunopharmacol. 1989;11(2):185-90.

A Kondratskyi et al. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014 Apr 24;5(4):e1193.

Cell Signaling & Oncology Akt PI3K-Akt-mTOR EC 2.7.11.1

MLCK, Akt and STIM1 inhibitor

Chemical name

1-(5-Chloronaphthalen-1-ylsulfonyl)-1,4-diazepane hydrochloride

Parent CAS No.

[110448-31-2]

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ML-9 hydrochloride

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Chemical name

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