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Featured Products
Axon 2369
CAS [1048371-03-4]
MF C17H13NO3MW 279.29
PARP-2 inhibitor with >26 fold selectivity over PARP1 (IC50 values 8.0 µM and 0.3 µM for PARP1 and PARP2, respectively) that exacerbates oxygen-glucose deprivation (OGD) injury in the hippocampus, but significantly attenuates OGD damage in mixed cortical cell cultures at concentrations high enough to inhibit both PARP1 and PARP2. UPF 1069 is a valuable tool to explore the function of PARP-2 in biological systems and to examine the different roles of PARP isoenzymes in the mechanisms of cell death and survival.
5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one
[1048371-03-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2021 Spring Edition
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