ML346 is an activator of Hsp70 (EC50 value of 4.6 μM; HeLa cell toxicity assay). ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2. ML346 has good chemical stability, is not reactive with excess glutathione, and is cell permeable.

KEYWORDS: ML346 | supplier | Hsp70 activator | CID 767276 | ML 346 | ML-346 | CID767276 | CID-767276 | CAS [100872-83-1] | CAS [1423118-63-1] | Unfolded Protein Response (Non Selective) | Hsp70 | Activator | Enzymes | ARE | Heat Shock Response | HSR | Probe | Proteostasis | HSF-1