Product Description

E-64, also known as Epoxysuccinyl-L-leucylamido-(4-guanidino)butane (CAS: 66701-25-5), is a protease inhibitor , and its binding modes with papain, actinidin, cathepsin L, and cathepsin K have been reviewed at the atomic level. E-64 has been widely used as a potent and irreversible (covalent-type) inhibitor for many cysteine proteases such as papain, ficin, actinidin, cathepsin B and L. E-64 will not inhibit serine proteases (except trypsin), and it inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition; it is permeable in cells and tissues & has low toxicity.

As one of the UK’s leading chemical distributors and manufacturers, you can trust Apollo to deliver the solution you need. We supply E-64 to clients in Pharma, R & D, Process Chemistry and also to Academic institutions. 

We can can facilitate bulk-orders, manufacture and distribution of E-64.

If you have any questions about how to order CAS 66701-25-5, please get in touch with our team today.