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Phosphocreatine disodium salt

Catalog No.
B7648
A phosphate reservoir used to regenerate ATP during skeletal muscle contraction
Grouped product items
SizePriceStock Qty
5g
$65.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Phosphocreatine (also known as creatine phosphate) disodium salt is a phosphorylated creatine molecule that may serve as a quickly accessible reserve of high-energy phosphates in skeletal muscle, myocardium as well as the brain. Phosphocreatine can offer a phosphate group to ADP for ATP synthesis, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase. Thus, phosphocreatine disodium salt could be used as a substrate for the determination of creatine kinase, and is used to regenerate ATP during skeletal muscle contraction.?

References:

1.?Wallimann T, Wyss M, Brdiczka D, et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochemistry Journal, 1992, 281: 21-40.

2.?Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutrition Reviews, 1999, 57(2): 45-50.

3.?Qaed E, Wang J, Almoiliqy M, et al. Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxidative Medicine and Cellular Longevity, 2019, 2019: 6521218.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt255.08
Cas No.922-32-7
FormulaC4H8N3Na2O5P
Solubilityinsoluble in ETOH; insoluble in DMSO; ≥54.6 mg/mL in H2O
Chemical Namesodium (E)-(amino((carboxymethyl)(methyl)amino)methylene)phosphoramidate
SDFDownload SDF
Canonical SMILESOC(CN(C)/C(N)=N/P([O-])([O-])=O)=O.[Na+].[Na+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[3]

Cell lines

H9C2 cells

Reaction Conditions

5 ~ 20?mM phosphocreatine for 2 h incubation

Applications

Phosphocreatine was found to provide a significant protective effect in H9C2 cells injured by exposure to methylglyoxal. Moreover, phosphocreatine at different concentrations (5 ~ 40?mM) has no lethality on normal H9C2 cells.
Animal experiment:[3]

Animal models

Wistar male rats with type 1 diabetes mellitus

Dosage form

20 or 50?mM

Administered intravenously once daily for 12 weeks

Applications

In diabetic rats, phosphocreatine significantly reduced heart sizes, reduced blood glucose levels, and improved the striation of myocardial fibers arranged regularly in treated groups. Phosphocreatine offered a defensive impact against diabetic cardiomyopathy.

Note

The technical data provided above is for reference only.

References:

1. Wallimann T, Wyss M, Brdiczka D, et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochemistry Journal, 1992, 281: 21-40.

2. Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutrition Reviews, 1999, 57(2): 45-50.

3. Qaed E, Wang J, Almoiliqy M, et al. Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxidative Medicine and Cellular Longevity, 2019, 2019: 6521218.

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