Cefdinir

Catalog No.

A8391

Third generation cephalosporin antibiotic

Grouped product items
Size	Price	Stock
10mM (in 1mL DMSO)	$90.00	In stock
1g	$80.00	In stock
5g	$260.00	In stock

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Cefdinir is a Cephalosporin antibiotic that is structurally similar to Cefixime.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	395.41
Cas No.	91832-40-5
Formula	C₁₄H₁₃N₅O₅S₂
Solubility	insoluble in EtOH; insoluble in H2O; ≥19.55 mg/mL in DMSO
Chemical Name	(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SDF	Download SDF
Canonical SMILES	C=CC1=C(N2C(C(C2=O)NC(=O)C(=NO)C3=CSC(=N3)N)SC1)C(=O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Animal experiment [1]:
Animal models	Acute kidney injury in male Wistar rat models
Dosage form	10 mg/kg(p.o.)
Application	After cisplatin administration, rats were orally administered cefdinir on day 6. It was observed that cefdinir significantly increased plasma exposure compared to the control group. At the same time, cumulative urinary excretion was significantly reduced in the cisplatin-induced AKI group. It could be estimated that morbid condition could significantly affect cefdinir's release in vivo. These results indicated that under the conditions of cisplatin-induced AKI, the pharmacokinetics of cefdinir changed significantly.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Wang H, Sun P, Wang C, Meng Q, Liu Z, Huo X, Sun H, Ma X, Peng J, Liu K. Pharmacokinetic changes of cefdinir and cefditoren and its molecular mechanisms in acute kidney injury in rats. J Pharm Pharmacol. 2018 Nov;70(11):1503-1512. doi: 10.1111/jphp.12994. Epub 2018 Jul 25. PMID: 30047127.

Purity = 99.65%