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- (S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of the inducible nitric oxide synthase (iNOS). Nitric oxide synthases, composed of the constitutive and the inducible isoforms, are a family of enzymes responsible for catalyzing the production of nitric oxide (NO) from L-arginine. The inducible isoform, i.e. iNOS, can be induced in various cells, including macrophages, by a variety of agents such as endotoxin, and thereby produces NO as an immune defense mechanism. Enhanced NO formation has been implied in the pathophysiology of a variety of diseases, such as circulatory shock. Thus, (S)-methylisothiourea sulfate, as a selective iNOS inhibitor, may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of iNOS.?
Reference:
1. Szabó C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91(26): 12472-12476.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 278.36 |
| Cas No. | 867-44-7 |
| Formula | C4H14N4O4S3 |
| Solubility | insoluble in EtOH; insoluble in DMSO; ≥11.9 mg/mL in H2O |
| Chemical Name | methyl carbamimidothioate hemisulfate |
| SDF | Download SDF |
| Canonical SMILES | NC(SC)=N.NC(SC)=N.OS(O)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
J774.2 macrophages and rat aortic vascular smooth muscle cells |
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Reaction Conditions |
100 nM ~100 μM (S)-methylisothiourea sulfate |
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Applications |
In J774.2 macrophages and rat aortic vascular smooth muscle cells, (S)-methylisothiourea sulfate exhibited more potent inhibitory effects on lipopolysaccharide (LPS)-induced nitrite production than any other known inhibitor of NOS, such as NG-amino-L-arginine. |
| Animal experiment:[1] | |
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Animal models |
Male Wistar rats, 260 ~ 320 g |
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Dosage form |
0.01 ~ 3 mg/kg Intravenous administration |
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Applications |
S-Methylisothiourea sulfate dose-dependently reversed the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Szabó C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91(26): 12472-12476. |
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Quality Control & MSDS
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Chemical structure
