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Wnt agonist 1

Catalog No.
B6059
agonist of Wnt signaling pathway
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$72.00
In stock
10mg
$64.00
In stock
50mg
$264.00
In stock
200mg
$485.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway [1].

The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation [1].

Wnt agonist 1 is a cell-permeable Wnt signaling pathway agonist. Wnt agonist 1 induced b-catenin- and TCF-dependent transcriptional activity in a dose-dependent way with EC50 of 0.7 μM. In Xenopus embryos, treatment with Wnt agonist 1 (10 μM) from developmental stage 10.5 to stage 40 resulted in substantial head defects, such as diminished heads and complete loss of eyes, and reduced eyes and heads. This phenotype is similar to that which results from Wnt over-expression in head specification during early embryonic development.

Reference:
Liu J, Wu X, Mitchell B, et al.? A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt386.83
Cas No.853220-52-7
FormulaC19H19ClN4O3
SynonymsBML-284
Solubility≥38.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Chemical Name(Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-(2-imino-6-(3-methoxyphenyl)-2,3-dihydropyrimidin-4(1H)-ylidene)methanamine hydrochloride
SDFDownload SDF
Canonical SMILESCOC1=CC=CC(C(NC2=N)=C/C(N2)=N/CC3=CC4=C(OCO4)C=C3)=C1.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control