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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Raloxifene HCl（LY139481）is a potent and selective of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM [1].
Raloxifene HCl（LY139481）is a selective and uncompetitive of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM for phthalazine oxidase in human liver cytosol. In addition, Raloxifene has been found to be a potent inhibitor for the three oxidation reactions with the Ki values of 0.87nM, 1.2nM and 1.4nM for phthalazine oxidation, vanillin oxidation and nicotine-△1’(5‘)-iminium ion oxidation, respectively. And the inhibition of Raloxifene HCl is not time-dependent fashion. Apart from these, Raloxifene HCl has been reported to noncompetitively inhibit the aldehyde oxidase-catalyzed reduction reaction with the Ki value of 52nM [1].
References:[1] Obach RS.Potent inhibition of human liver aldehyde oxidase by raloxifene.
Drug Metab Dispos. 2004 Jan;32(1):89-97.
