Loteprednol etabonate

Catalog No.

B2106

potent glucocorticoid receptor agonist

Grouped product items
Size	Price	Stock
10mM (in 1mL DMSO)	$61.00	In stock
10mg	$55.00	In stock
100mg	$231.00	In stock

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	466.95
Cas No.	82034-46-6
Formula	C24H31ClO7
Solubility	insoluble in H2O; insoluble in EtOH; ≥16.95 mg/mL in DMSO
Chemical Name	chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
SDF	Download SDF
Canonical SMILES	O[C@@H]1[C@H]([C@@](C)(C=C2)C3=CC2=O)[C@@H](CC3)[C@H](CC4)[C@@](C1)(C)[C@]4(C(OCCl)=O)OC(OCC)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Animal experiment [1]:
Animal models	Rats
Dosage form	0.5～10 mg/kg (i.v.)
Application	The results showed that Loteprednol etabonate showed a rapid dose-dependent elimination effect, with a total blood clearance of more than 60 ml/min/kg. Loteprednol etabonate, which is absorbed systemically after topical administration, can be quickly converted into inactive metabolites and is mainly cleared from the body by bile and urine.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Bodor N, Wu WM, Murakami T, Engel S. Soft drugs. 19. Pharmacokinetics, metabolism and excretion of a novel soft corticosteroid, loteprednol etabonate, in rats. Pharm Res. 1995 Jun;12(6):875-9. PubMed PMID: 7667193.

Purity = 99.94%