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Bradykinin (acetate)

Catalog No.
C4126
inflammatory mediator
Grouped product items
SizePriceStock Qty
10mg
$59.00
In stock
25mg
$122.00
Ship with 10-15 days
50mg
$186.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].

Bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. It also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. Bradykinin is an inflammatory mediator. The Bradykinin B1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. The Bradykinin B2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.

In cultured endothelial cells, bradykinin promoted a rapid dissociation of the eNOS:B2 receptor complex [2]. In the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with B2 receptors and stimulating tachykinin release from sensory nerves [3].

In healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-PGF1a , the stable hydrolysis product of prostacyclin (PGI2). So bradykinin may have a use as a probe of PG12 production in vivo in pathological states [1].

References:
[1].? Barrow SE, Dollery CT, Heavey DJ, et al. Effect of vasoactive peptides on prostacyclin synthesis in man. Br J Pharmacol. 1986 Jan;87(1):243-7.
[2].? Ju H, Venema VJ, Marrero MB, et al. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase. J Biol Chem. 1998 Sep 11;273(37):24025-9.
[3].? Figini M, Emanueli C, Grady EF, et al. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol. 1997 Apr;272(4 Pt 1):G785-93.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt1120.3
Cas No.6846-03-3
FormulaC50H73N15O11·XC2H4O2
SynonymsH 1970
Solubility≥113 mg/mL in DMSO with gentle warming; ≥113.5 mg/mL in EtOH with gentle warming; ≥226.6 mg/mL in H2O
Chemical Name(S)-2-((S)-2-((S)-1-((S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-guanidinopentanoic a
SDFDownload SDF
Canonical SMILESO=C([C@H](CCC1)N1C([C@@H](N)CCCNC(N)=N)=O)N(CCC2)[C@@H]2C(NCC(N[C@H](C(N[C@@H](CO)C(N(CCC3)[C@@H]3C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O.CC(O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Human umbilical vein endothelial cells and monocytes

Reaction Conditions

10-8 ~ 10-5 mol/l bradykinin for 1 h pretreatment

Applications

Exogenous bradykinin markedly inhibited tissue factor expression in mRNA and protein level induced by lipopolysaccharides in a dose-dependent manner.
Animal experiment:[1]

Animal models

C57/BL6 mice

Dosage form

10 mg/kg/d

Injected intraperitoneally for 3 days ahead of inferior cava vein ligation and for another 2 days after surgical procedure

Applications

Intraperitoneal injection of C57/BL6 mice with bradykinin inhibited the thrombus formation induced by ligation of inferior vena cava.

Note

The technical data provided above is for reference only.

References:

1. Dong R, Chen W, Feng W, et al. Exogenous bradykinin inhibits tissue factor induction and deep vein thrombosis via activating the eNOS/phosphoinositide 3-kinase/Akt signaling pathway. Cellular Physiology and Biochemistry, 2015, 37(4): 1592-1606.

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