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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Hypoxanthine is a natural purine derivative, with potential to be used as a free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury via oxygen radical production, and is thus involved in the pathogenesis of many diseases. Hypoxanthine also modulates a variety of other processes because it can react with benzodiazepine receptors and inhibit phosphodiesterase in the brain. Hypoxanthine has been reported to be used as an indicator of hypoxia.?
References:
1.?Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.
2.?Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.
Cell lines
Rat cerebral cortex synaptosomes
Reaction Conditions
400 μM
Applications
Hypoxanthine alone inhibited [3H] diazepam binding by 11.7%. When hypoxanthine was combined with inosine, the inhibition on [3H] diazepam binding could reach 34.3%. Thus, hypoxanthine could play a neuromodulatory role as well as affect benzodiazepine action.
Note
The technical data provided above is for reference only.
1. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.
2. Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.
