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Calcium Ionophore I
Calcium Ionophore I, also known as CA 1001 or ETH 1001, is a Ca2+-selective ionophore [1][2].
Ionophores can selectively change the ionic permeability of a membrane and therefore can be used to mimic the properties of the ion carriers normally found in biological membranes and to study membrane function [2].
Calcium Ionophore I is a Ca2+-selective neutral carrier. In Ca2+ loaded IOVs derived from human RBCs, ETH 1001 promoted Ca2+ flux across RBC membranes. The amount of Ca2+ in cells treated with ETH 1001 was significantly higher than in control cells. In the presence of external Ca2+, ETH 1001 was capable of transporting Ca2+ into RBCs [3]. CA 1001 was also used to construction of the Ca2+-selective membrane microelectrode [4][5].
References:
Dagostino M, Lee CO.? Neutral carrier Na+- and Ca2+-selective microelectrodes for intracellular application. Biophys J. 1982 Dec;40(3):199-207.
Caroni P, Gazzotti P, Vuilleumier P, et al.? Ca2+ transport mediated by a synthetic neutral Ca2+ -ionophore in biological membranes. Biochim Biophys Acta. 1977 Nov 1;470(3):437-45.
Hinds TR, Vincenzi FF.? The effect of ETH 1001 on ion fluxes across red blood cell membranes. Cell Calcium. 1985 Jun;6(3):265-79.
Lücke A, Lehmenkühler A, Speckmann EJ.? The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42.
Lee MH, Yoo CL, Lee JS, et al.? Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7.
Physical Appearance | A solution in ethanol |
Storage | Store at -20°C |
M.Wt | 684.99 |
Cas No. | 58801-34-6 |
Formula | C38H72N2O8 |
Solubility | Soluble in DMSO |
Chemical Name | (17R,18R)-diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontane-1,34-dioate |
SDF | Download SDF |
Canonical SMILES | C[C@H]([C@H](OCC(N(CCCCCCCCCCCC(OCC)=O)C)=O)C)OCC(N(C)CCCCCCCCCCCC(OCC)=O)=O |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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