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- (R)-(+)-Atenolol
(R)-(+)-Atenolol
(R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol [1].
Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. Atenolol is used for a number of conditions including hypertension, angina, long QT syndrome, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, and the symptoms of alcohol withdrawal. β1-adrenergic receptor is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.
Pharmacokinetic data of the time course of plasma concentrations over 24 h following oral administration of 50 mg (R)-(+)-Atenolol revealed that the Cmax, AUC, and t1/2 values were 326±87 ng/ml, 2599±639 ng×h/ml, and 8.9±2.9 h, respectively [1].
Reference:
[1] Stoschitzky K, Egginger G, Zernig G, et al. Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[J]. Chirality, 1993, 5(1): 15-19.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 266.3 |
Cas No. | 56715-13-0 |
Formula | C14H22N2O3 |
Solubility | ≤5mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide |
Chemical Name | 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide |
SDF | Download SDF |
Canonical SMILES | NC(CC1=CC=C(OC[C@H](O)CNC(C)C)C=C1)=O |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)