Quinidine
Quinidine is a clinical antiarrhythmic drug, which is used to treat abnormal heart rhythms and malaria[1].?
The application of quinidine in the bath results in a dose-dependent decrease in the peak amplitude of Ik. Kd for Ik block at 0 mV is estimated to be 41 μM[1].?
In rats, quinidine inhibits metabolism of amphetamine. Quinidine pretreatment significantly reduces excretion of p-hydroxyamphetamine at 24 and 48 hours, to 7.2% and 24.1% of vehicle control levels, and significantly increases excretion of amphetamine between 24 and 48 hours to 542%[2].?
Reference:
[1]. Kehl S J, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol, 1991, 103(3): 1807-13.
[2]. Moody D E, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol, 1990, 14(5): 311-7.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 324.42 |
| Cas No. | 56-54-2 |
| Formula | C20H24N2O2 |
| Solubility | insoluble in H2O; ≥10.32 mg/mL in EtOH with ultrasonic; ≥11.95 mg/mL in DMSO |
| Chemical Name | (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol |
| SDF | Download SDF |
| Canonical SMILES | O[C@H](C(C1=C2)=CC=NC1=CC=C2OC)[C@@H]3[N@@]4C[C@@H](C=C)[C@@H](CC4)C3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
