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Isoxanthopterin

Catalog No.
C4558
interferes with RNA and DNA synthesis
Grouped product items
SizePriceStock Qty
50mg
$147.00
Ship with 5-10 days
100mg
$244.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Isoxanthopterin interferes with RNA and DNA synthesis.

Isoxanthopterin, a natural intermediate in the pteridine pathway, plays critical roles in pigmentation and cell division.

In vitro: Isoxanthopterin was identified as a pteridine of wide natural occurrence and was reported to exerts an inhibitory action on the synthesis of ribosomal RNA, possibly soluble RNA and on DNA in developing eggs of the milkweed bug Oncopeltus fasciatus. Such effects were measured by partially incubating dechorionated eggs in a solution containing isoxanthopterin and radioactive uridine or thymidine, and then testing the incorporation of the isotope into ribosomal RNA or DNA. The detailed mechanism of this inhibition had been discussed, and the tentative conclusion was agreed that it was due to an interaction between the pteridine and the nucleic acid (most probably DNA) [1].

In vivo: Previous animal study showed that rats with inherited retinal dystrophy appeared to differ from healthy rats by an elevated isoxanthopterin excretion in urine. RCS rats responded to feeding of monapterin with an increase of isoxanthopterin excretion. This phenomenon supported the idea that the RCS rat had an increased xanthinoxidase activity compared with healthy rats [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Lagowski, J.?M. and Forrest, H.S. Interaction in vitro between isoxanthopterin and DNA. Proceedings of the National Academy of Sciences of the United States of America 58(4), 1541-1547 (1967).
[2] G.? Cremer-Bartels, H. Gerding, L. Hanneken and K. Krause. Isoxanthopterin Excretion of Rats with Inherited Retinal Dystrophy. Pteridines Vol. 2, 1990, pp. 103 -105.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt179.1
Cas No.529-69-1
FormulaC6H5N5O2
SynonymsNSC 118090,NSC 614991
Solubility≤5mg/L in H2O
Chemical Name2-amino-4,7(3H,8H)-pteridinedione
SDFDownload SDF
Canonical SMILESO=C1C=NC(C(N=C(N)N2)=O)=C2N1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Isoxanthopterin