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Terfenadine

Catalog No.
A8534
Histamine H1-receptor antagonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$60.00
In stock
100mg
$50.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Terfenadine is a histamine H1-receptor antagonist, which blocks HERG and KATP (KIR6) channels. The IC values for Terfenadines inhibitory activity against these channels is 204nM for HERG and 1.2μM for KATP. Studies show that Terfenadine inhibits the delayed rectifier K+ in ventricular myocytes. Terfenadine is converted into its more active form, terfenadine carboxylate by the enzyme CYP3A4.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt471.67
Cas No.50679-08-8
FormulaC32H41NO2
Solubilityinsoluble in H2O; ≥18 mg/mL in DMSO; ≥8.06 mg/mL in EtOH with ultrasonic
Chemical Name1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol
SDFDownload SDF
Canonical SMILESCC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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