Hydrocortisone
Hydrocortisone is a main glucocorticoid secreted by the adrenal cortex.
- 1. Jie Xia, Lixing Zhang, et al. "Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis." Sci Bull (Beijing). 2024 Dec 27:S2095-9273(24)00949-6. PMID: 39800628
- 2. Jie Xia, Lixing Zhang, et al. "IL1R2 blockade alleviates immunosuppression and potentiates anti-PD-1 efficacy in triple-negative breast cancer." Cancer Res. 2024 Apr 24. PMID: 38657120
- 3. Yunxiao Liang, Xin Tang, et al. "Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by?Targeting the TGF-β1/SMAD3 Signaling Pathway." Int J Mol Sci. 2023 Mar 16;24(6):5703. PMID: 36982775
- 4. Meng-Li Wu, Feng-Liang Liu, et al. "Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice." Zool Res. 2022 May 18;43(3):457-468. PMID: 35503561
- 5. Lu Gan, Qiyong Li, et al. "Glucocorticoids rapidly promote YAP phosphorylation via the cAMP-PKA pathway to repress mouse cardiomyocyte proliferative potential." Mol Cell Endocrinol. 2022 Mar 10;548:111615. PMID: 35278645
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 362.46 |
| Cas No. | 50-23-7 |
| Formula | C21H30O5 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥13.3 mg/mL in DMSO |
| Chemical Name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| SDF | Download SDF |
| Canonical SMILES | C[C@@]1([C@](C(CO)=O)(O)CC2)[C@@]2([C@@]([H])([C@]([H])([C@H](C1)O)[C@@]3(C)CC4)CCC3=CC4=O)[H] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
human lung microvascular endothelial cells |
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Preparation method |
The solubility of this compound in DMSO is >13.3 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37°C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
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Reacting condition |
4 or 6 μM; 16 h |
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Applications |
In human lung microvascular endothelial cells, Hydrocortisone (HC) induced a concentration-dependent but biologically minor barrier enhancing and protective effect. The combination of HC (4 μM) and ascorbic acid (VitC) (1000 μM) pre- or post-treatment significantly reversed the LPS-induced barrier dysfunction. |
| Animal experiment [2]: | |
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Animal models |
6-hydroxydopamine (6-OHDA)-induced Parkinson’s disease (PD) mouse models |
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Dosage form |
0.4 mg/kg; intraperitoneal injection, 7 consecutive days |
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Application |
In Parkinson’s disease (PD) mouse models, Hydrocortisone caused approximate two-fold increase of parkin expression in selected brain subregions (striatum, ventral midbrain, and cerebellum), which was responsible for cell survival against oxidative stress. Hydrocortisone also increased CREB expression. Hydrocortisone pretreatment markedly enhanced dopaminergic neuronal survival against 6-OHDA intoxication. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1] Barabutis N1, Khangoora V2, Marik PE2, et al. Hydrocortisone and Ascorbic Acid synergistically prevent and repair LPS-induced pulmonary endothelial barrier dysfunction. Chest. 2017 Jul 21. pii: S0012-3692 (17) 31276-X. [2] Ham S1, Lee YI2, 3, Jo M1, et al. Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model. Sci Rep. 2017 Apr 3; 7 (1): 525. |
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Quality Control & MSDS
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Chemical structure
