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(S)-(-)-Propranolol hydrochloride

Catalog No.
B6466
A β-adrenoceptor antagonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$61.00
In stock
100mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

(S)-(-)-Propranolol hydrochloride is a more active enantiomer of propranolol, acting as a?β-adrenoceptor antagonist?with log Kd values being -8.16, -9.08 and -6.93 for human β1-, β2- and β3-adrenoceptors stably expressed in Chinese hamster ovary cells, respectively. β-Adrenoceptor antagonists are one of the most commonly used classes of drugs in cardiovascular medicine (hypertension, ischemic heart disease and heart failure) as well as in the management of anxiety, migraine and glaucoma. In addition, (S)-(-)-propranolol hydrochloride is also a non-specific serotonin receptor antagonist, capable of inhibiting the behavioral responses to increased brain 5-hydroxytryptamine (5-HT).?

References:

1.?Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British Journal of Pharmacology, 2005, 144(3): 317-322.

2.?Costain DW, Green AR. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology, 1978, 64(2): 193-200.

3.?Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. British Journal of Pharmacology, 1968, 34(1): 43-55.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt295.81
Cas No.4199-10-4
FormulaC16H21NO2·HCl
Solubility≥15.65 mg/mL in H2O; ≥2.9 mg/mL in EtOH with gentle warming and ultrasonic; ≥57.5 mg/mL in DMSO
Chemical Name(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
SDFDownload SDF
Canonical SMILESO[C@H](COC1=CC=CC2=CC=CC=C12)CNC(C)C.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[3]

Animal models

Cats anaesthetized with halothane

Dosage form

From 0.05 mg/kg to the dose at which the arrhythmia to adrenaline was abolished

Given intravenously

Applications

Both (S)-(-)-propranolol and (S)-(+)-propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (S)- (-)-propranolol was 0.09 ± 0.02 mg/kg whereas that of (S)-(+)-propranolol was 4.2 ± 1.2 mg/kg.

Note

The technical data provided above is for reference only.

References:

1. Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British Journal of Pharmacology, 2005, 144(3): 317-322.

2. Costain DW, Green AR. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology, 1978, 64(2): 193-200.

3. Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. British Journal of Pharmacology, 1968, 34(1): 43-55.

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