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Andarine

Catalog No.
A2150
Androgen receptor agonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$66.00
In stock
5mg
$55.00
In stock
25mg
$132.00
In stock
100mg
$220.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Andarine (S-4) is a selective inhibitor of AR with Ki value of 4 nM [1].

Androgen receptor (AR), also known as nuclear receptor subfamily 3, group C, member 4, is a type of nuclear receptor and plays an important role in DNA-binding transcription factor that regulates gene expression [2].

Andarine is a potent AR inhibitor and has a higher affinity with the reported AR inhibitor S-1, S-2 and S-3. Using a cotransfection system, it was shown that Andarine stimulated AR-mediated transcription as high as 93% at the concentration of 10 nM. [1].

In male Sprague-Dawley rat model, administration of Andarine resulted in the growth in prostate, seminal vesicles, and levator ani muscle at a dose-dependent manner and promoted their weight being maximally to 33.8, 28.2 and 101% of intact controls, respectively. Further, it was revealed that the ED50 value of Andarine functioning on prostate, seminal vesicles, and levator ani muscle was 0.43±0.01, 0.55±0.02, and 0.14±0.01 mg/day [1].

References:
[1].? Yin, D., et al., Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther, 2003. 304(3): p. 1334-40.
[2].? Thevis, M., et al., Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom, 2011. 25(15): p. 2187-95.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt441.36
Cas No.401900-40-1
FormulaC19H18F3N3O6
Solubility≥21 mg/mL in DMSO; insoluble in H2O; ≥29.15 mg/mL in EtOH
Chemical Name(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
SDFDownload SDF
Canonical SMILESC(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description Andarine is a selective non-steroidal agonist of androgen receptor (AR) with Ki value of 4 nM.
Targets androgen receptor          
IC50 4 nM (Ki)          

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