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- Cinacalcet HCl
Cinacalcet HCl
Cinacalcet HCl (AMG 073), the second-generation calcimimetic, is a potent agonist of calcium-sensing receptor (CaR) with an EC50 value of 2.8 μm [1].
Cinacalcet HCl showed to be safe for the secondary hyperparathyroidism treatment. Besides, cinacalcet HCl has been proved to reduce parathyroid hormone (PTH) levels significantly while reducing the calcium x phosphorus product and serum phosphorus levels at the same time [1].
Administered orally with cinacalcet in Rice H-500 tumor?bearing mice has shown a significant reduction of blood ionized calcium, serum total calcium concentrations and serum PTHrP levels [2].
References:
[1] Ure?a P1,?Fraz?o JM. Calcimimetic agents: review and perspectives. Kidney Int Suppl.?2003 Jun;(85):S91-6.
[2] Colloton M1,?Shatzen E,?Wiemann B,?Starnes C,?Scully S,?Henley C,?Martin D.Cinacalcet attenuates hypercalcemia observed in mice bearing either Rice H-500 Leydig cell or C26-DCT colon tumors. Eur J Pharmacol.?2013 Jul 15;712(1-3):8-15.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 393.87 |
| Cas No. | 364782-34-3 |
| Formula | C22H23ClF3N |
| Solubility | insoluble in H2O; ≥17.85 mg/mL in DMSO; ≥56 mg/mL in EtOH |
| Chemical Name | N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
