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- 3-aminobenzamide
3-aminobenzamide
3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2 [1].
In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and decreases diabetes-induced podocyte depletion [2].
[1]. Radovits T, et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.
[2]. Szabo C, et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12.
- 1. Grunewald ME, Chen Y, et al. "The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression." PLoS Pathog. 2019 May 16;15(5):e1007756. PMID:31095648
- 2. Waldman M, Nudelman V, et al. "PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis." Exp Cell Res. 2018 Oct 23. pii: S0014-4827(18)31064-4. PMID:30359575
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 136.15 |
| Cas No. | 3544-24-9 |
| Formula | C7H8N2O |
| Synonyms | PARP-IN-1 |
| Solubility | ≥23.45 mg/mL in H2O with ultrasonic; ≥48.1 mg/mL in EtOH with ultrasonic; ≥7.35 mg/mL in DMSO |
| Chemical Name | 3-aminobenzamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC(=C1)N)C(=O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| 3-aminobenzamide is a potent inhibitor of PARP with IC50 of <50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. Phase 2. | ||||||
| Targets | PARP | |||||
| IC50 | 50 nM | |||||
Quality Control & MSDS
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Chemical structure
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