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Spermidine trihydrochloride

Catalog No.
B6523
A NMDA receptor agonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
100mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Spermidine trihydrochloride is an agonist of the N-methyl-D-aspartate (NMDA) receptor. The NMDA receptor is a ligand-gated ion channel complex with multiple regulatory sites in addition to the glutamate recognition site. Spermidine binds to the polyamine modulatory site of the NMDA receptor, and has been classified as agonists at this site based on their ability to enhance the binding of MK801 (a noncompetitive antagonist of the NMDA receptor). Thus, spermidine potentially enhances the neuroprotective effect of NMDA antagonists.?

References:

1.?Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170.

2.?Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na?, K?-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86.

3.?Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt254.63
Cas No.334-50-9
FormulaC7H19N3·3HCl
Solubilityinsoluble in DMSO; insoluble in EtOH; ≥10 mg/mL in H2O
Chemical NameN1-(3-aminopropyl)butane-1,4-diamine trihydrochloride
SDFDownload SDF
Canonical SMILESNCCCCNCCCN.Cl.Cl.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[2]

Cell lines

Hippocampal slices and homogenates from rats

Reaction Conditions

0.05 ~ 10 μM spermidine for 30 min incubation

Applications

Spermidine at the concentrations of 0.5 and 1 μM decreased Na+, K+-ATPase activity in slices, but not in homogenates. Spermidine also increased NO2 plus NO3 (NOx) levels in slices.
Animal experiment:[3]

Animal models

Male Swiss-Webster mice

Dosage form

200 μg/mouse

Orally

Applications

Spermidine at 200 μg/mouse did not alter the basal cGMP level in mouse cerebellum. Moreover, spermidine attenuated responses mediated through NMDA, NMDA-associated glycine receptor and quisqualate receptors. Since spermidine is widely distributed in neural and non-neural tissues, it plays a potential key role in cell differentiation and growth.

Note

The technical data provided above is for reference only.
?

References:

1. Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170.

2. Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na?, K?-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86.

3. Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206.

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