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SR 0987

Catalog No.
C4281
agonist of the T cell-specific isoform of RORγ
Grouped product items
SizePriceStock Qty
5mg
$116.00
Ship with 5-10 days
10mg
$189.00
Ship with 5-10 days
25mg
$365.00
Ship with 5-10 days
50mg
$630.00
Ship with 5-10 days
100mg
$998.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

SR 0987 is an agonist of RORγt with EC50 value of ~800 nM for inducing reporter gene expression [1].

RORγt (retinoic acid receptor-related orphan receptor-γt), the T cell-specific isoform of RORγ, is the key lineage-defining transcription factor to initiate the differentiation program of TH17 and Tc17 cells, cells that have demonstrated anti-tumor efficacy [1].

SR 0987 is a RORγt agonist. In murine EL4 T lymphocytes, SR 0987 increased expression of IL17 while repressing the expression of the checkpoint receptor PD-1, suggesting that SR 0987 enhanced protective immunity by regulating expression of IL17 and PD-1 while maintaining the cytotoxic ability of these cells. In both the 5xRORE and IL17 promoter transfected cells, SR0987 concentration dependently induced reporter gene expression with an EC50 of ~800 nM. SR0987 also concentration dependently increased interaction of RORγt with the SRC1-3 NR box peptide [1].

Reference:
[1].  Chang MR, Dharmarajan V, Doebelin C, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt397.7
Cas No.303126-97-8
FormulaC16H10ClF6NO2
Solubility≤30mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
SDFDownload SDF
Canonical SMILESClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

SR 0987