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- Luliconazole
Luliconazole
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 354.28 |
| Cas No. | 187164-19-8 |
| Formula | C14H9Cl2N3S2 |
| Synonyms | NND 502; Lulicon |
| Solubility | insoluble in H2O; ≥17.71 mg/mL in DMSO; ≥32.53 mg/mL in EtOH with gentle warming |
| Chemical Name | (2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile |
| SDF | Download SDF |
| Canonical SMILES | C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Dermatophytes, zygomycetes, filamentous fungi |
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Preparation method |
The solubility of this compound in DMSO is ≥17.714 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
0.004～0.008 μg/ml |
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Applications |
The results show that dermatophytes are most sensitive to Luliconazole (MIC ≤ 0.004～0.008 μg/ml). At low concentrations (MIC ≤ 0.004～0.125 μg/ml), Luliconazole inhibits all filamentous fungi except zygomycetes. |
| Animal experiment [1]: | |
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Animal models |
Guinea pig |
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Dosage form |
1% cream |
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Application |
The results of the study showed that Luliconazole (1% cream) was slightly less effective than terbinafine. Luliconazole-treated guinea pigs have a small amount of conidial hair. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Uchida K, Nishiyama Y, Yamaguchi H. In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother.2004 Aug;10(4):216-9. PubMed PMID: 15365862. [2]. Ghannoum MA, Long L, Kim HG, Cirino AJ, Miller AR, Mallefet P. Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Med Mycol. 2010 May;48(3):491-7. doi: 10.3109/13693780903373811. PubMed PMID: 20370362. |
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Quality Control & MSDS
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Chemical structure
