Bupivacaine HCl
Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.Bupivacaine hydrochloride is an effective local anesthetic agent. It has a rapid onset time, a high frequency of surgical anesthesia, a long duration, and a low incid
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 324.89 |
| Cas No. | 18010-40-7 |
| Formula | C18H28N2O·HCl |
| Solubility | ≥10.25 mg/mL in DMSO; ≥16.23 mg/mL in H2O with ultrasonic; ≥69.2 mg/mL in EtOH |
| Chemical Name | 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
FDB muscle fibers |
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Preparation method |
The solubility of this compound in DMSO is > 10.3 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
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Reacting condition |
1 mM; 40 mins |
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Applications |
In FDB muscle fibers treated with 1 mM Bupivacaine HCl for 40 mins, the TMRM signal was substantially lost and the fiber shortened significantly. The TMRM signal decreased within about 30 mins, and depolarization was inhibited by CsA, which indicated that Bupivacaine facilitated the opening of the permeability transition pore, eventually causing mitochondrial depolarization. |
| Animal experiment [2]: | |
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Animal models |
ACLT osteoarthritic rats |
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Dosage form |
0.5%, 10 mL; intra-articular injection; once a week for 5 consecutive weeks |
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Applications |
In ACLT osteoarthritic rats treated with Bupivacaine HCl, the relative weight-bearing values were significantly lower at the 6th and 7th weeks. Besides, Bupivacaine HCl did not show any significant effect on the viability and density of chondrocytes, as well as the histological characteristics of articular cartilage when compared with saline solution injections. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Irwin W, Fontaine E, Agnolucci L, Penzo D, Betto R, Bortolotto S, Reggiani C, Salviati G, Bernardi P. Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem. 2002 Apr 5;277(14):12221-7. [2]. Iwasaki K, Sudo H, Kasahara Y, Yamada K, Ohnishi T, Tsujimoto T, Iwasaki N. Effects of Multiple Intra-articular Injections of 0.5% Bupivacaine on Normal and Osteoarthritic Joints in Rats. Arthroscopy. 2016 Oct;32(10):2026-2036. | |
Quality Control & MSDS
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Chemical structure
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