IC50: 2.9 μM for antilipase effect

Kaempferol-3-O-rutinoside has been isolated from a crude ethyl acetate extract of A. mahidoliae leaves, which could enhance the in vitro migration of keratinocytes. Kaempferol and its glycosides have been reported to possess wound healing activity. Kaempferol and kaempferol-3-O-glucoside have been used in excision and incision wound healing in Wistar rats. Others from Ophioglossum vulgatum also showed wound healing activity via accelerating the cell migration of keratinocytes.

In vitro: It was found that Kaempferol-3-O-rutinoside was a potent in vitro inhibitor of α-glucosidase with over 8-times more activity than acarbose, which was the reference antidiabetic drug. In addition, Kaempferol-3-O-rutinoside displayed a synergistic effect with kaempferol and quercetin, two less potent flavonoid aglycones. However, the SAR profile of such drugs or drug combinations should be further discussed [1].

In vivo: Kaempferol-3-O-rutinoside and rutin were previously tested on normotensive pentothal anaesthetized rats for their cardiovascular activities. Results showed that kaempferol-3-O-rutinoside displayed a remarkable decrease in diastolic, systolic, mean arterial blood pressure as well as heart rate, while rutin showed no effect on any of these parameters [2].

Clinical trial: N/A

References:
[1] Habtemariam S.? A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside. Nat Prod Commun.2011 Feb;6(2):201-3.
[2] Mansoor Ahmad,Anwar-Ul-Hassan Gilani,Khalid Aftaband Viqar Uddin Ahmad.? Effects of kaempferol-3-O-rutinoside on rat blood pressure. Phytotherapy Research. Volume 7,Issue 4,pages 314–316.