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Cerulenin
Cerulenin is a widely used natural inhibitor of fatty acid synthase (FAS).?
In primary rat aortic endothelial cells, the inhibitor of fatty acid synthase and HMG-CoA reductase, Cerulenin (5 μg/mL) and Lovastatin, are used before palmitic acid added. The mRNA expression of IL-1β, TNFα, VCAM-1 and IL-6 are reduced while NO production is recovered with inhibitor treatment[2].?
In ob/ob mice, cerulenin effectively depletes fat content in the steatotic liver, which trigger a series of reactions: Decreased expression of PPARα and γ reduced UCP2 levels, increase liver ATP content, and reduce ROS production.?Elevated intracellular ATP levels and reduced ROS ultimately improved liver function.?
References:
[1]. Bitencourt T A, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med, 2013, 13(1): 229.
[2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol, 2012, 11(1): 144.
[3]. Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One, 2013, 8(9): e75980.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 223.3 |
Cas No. | 17397-89-6 |
Formula | C12H17NO3 |
Solubility | ≤20mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide |
Chemical Name | 2R,3S-epoxy-4-oxo-7,10-dodecadienamide |
SDF | Download SDF |
Canonical SMILES | C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)