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Cerulenin

Catalog No.
C4653
fatty acid synthase (FAS) inhibitor
Grouped product items
SizePriceStock Qty
5mg
$150.00
Ship with 5-10 days
10mg
$284.00
Ship with 5-10 days
50mg
$1,114.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Cerulenin is a widely used natural inhibitor of fatty acid synthase (FAS).?

In primary rat aortic endothelial cells, the inhibitor of fatty acid synthase and HMG-CoA reductase, Cerulenin (5 μg/mL) and Lovastatin, are used before palmitic acid added. The mRNA expression of IL-1β, TNFα, VCAM-1 and IL-6 are reduced while NO production is recovered with inhibitor treatment[2].?

In ob/ob mice, cerulenin effectively depletes fat content in the steatotic liver, which trigger a series of reactions: Decreased expression of PPARα and γ reduced UCP2 levels, increase liver ATP content, and reduce ROS production.?Elevated intracellular ATP levels and reduced ROS ultimately improved liver function.?

References:

[1]. Bitencourt T A, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med, 2013, 13(1): 229.

[2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol, 2012, 11(1): 144.

[3]. Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One, 2013, 8(9): e75980.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt223.3
Cas No.17397-89-6
FormulaC12H17NO3
Solubility≤20mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name2R,3S-epoxy-4-oxo-7,10-dodecadienamide
SDFDownload SDF
Canonical SMILESC/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Cerulenin