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Ryanodine

Catalog No.
B5092
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum
Grouped product items
SizePriceStock Qty
1mg
$546.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ryanodine is a selective ryanodine receptor (RyR) blocker, with IC50 value of 10 nM [1].?

RyR, expressed on the sarcoplasmic reticulum membranes of excitable cells, including smooth muscle myocytes, is important to the regulation of pulmonary as well as systemic vascular tone. Opening of clusters of RyRs gives rise to Ca2+ spark events which are particularly important for activation of the large-conductance Ca2+ and voltage-activated K+ channel in vascular smooth muscle [2].?

In canine pulmonary arterial smooth muscle cells exposed to 10 mM caffeine, ryanodine at the concentration of 10 μM reversibly inhibited induced Ca2+ increases [2]. In addition, ryanodine (0.4, 0.8, 1.6 and 10 μmol/L) was shown to differentiate between muscles of malignant hyperthermia (MH) susceptible and normal patients in terms of in vitro contracture response [3].?

In dogs, the lethal doses of ryanodine by injection were 50 ~ 300 μg/kg, which resulted in enophthalmos, followed by general spastic muscle rigidity, salivation, vomiting, and defecation. In mice, ryanodine exhibited low mammalian toxicity with intraperitoneal LD50 > 20 mg/kg, when compared with its toxicity on insects. Furthernomre, ryanodine affected the excitability and ion selectivity of K+ channels in insects but not in mammals [1].?

References:

[1]. Ujváry I. Chapter 3 - Pest Control Agents from Natural Products. Hayes' Handbook of Pesticide Toxicology (Third Edition). 2010, 119-229.

[2]. Ostrovskaya O, Goyal R, Osman N, et al. Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics, 2007, 323(1): 381-390.

[3]. Hopkins P M, Ellis F R, Halsall P J. Ryanodine contracture: a potentially specific in vitro diagnostic test for malignant hyperthermia. British Journal of Anaesthesia, 1991, 66(5): 611-613.

Product Citation

Chemical Properties

Physical AppearanceOff White solid
StorageDesiccate at -20°C
M.Wt493.55
Cas No.15662-33-6
FormulaC25H35NO9
Solubility<12.34mg/ml in DMSO;insoluble in ethanol
Chemical Name(3R,4R,4aR,4a1R,6R,6aR,7R,8S,8aR,9R,9aR)-4,4a1,6,7,8a,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate
SDFDownload SDF
Canonical SMILESO[C@@]1([C@@]([C@]2(C)C3)([C@H]4OC(C5=CC=CN5)=O)O)[C@]([C@@]4(C(C)C)O)(C)[C@]3(O)O[C@]1([C@@H]6O)[C@]2(CC[C@H]6C)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Ryanodine