UNC 0642
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 546.7 |
| Cas No. | 1481677-78-4 |
| Formula | C29H44F2N6O2 |
| Solubility | insoluble in H2O; ≥18.5 mg/mL in DMSO; ≥48.1 mg/mL in EtOH |
| Chemical Name | 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine |
| SDF | Download SDF |
| Canonical SMILES | CC(C)N1CCC(NC2=NC(N3CCC(F)(F)CC3)=NC4=C2C=C(OC)C(OCCCN5CCCC5)=C4)CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Kinase experiment [1]: | |
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Kinase selectivity assays |
Selectivity of UNC 0642 against a panel of 50 kinases was conducted using a standard off-chip mobility shift assay technology. |
| Cell experiment [1]: | |
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Cell lines |
PANC-1 and MDA-MB-231 cells |
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Preparation method |
The solubility of this compound in DMSO is > 18.5 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
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Reacting condition |
0, 0.5 or 1 μM; 2 weeks |
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Applications |
UNC 0642 concentration-dependently reduced clonogenicity in PANC-1 cells but it showed no effect on clonogenicity in MDA-MB-231 cells. Besides, UNC 0642 potently reduced cellular levels of H3K9me2 with low cell toxicity, which resulted in a good separation of functional potency and cell toxicity with a tox/function ratio of 88 in PANC-1 cells. |
| Animal experiment [1]: | |
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Animal models |
Male Swiss Albino mice |
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Dosage form |
5 mg/kg; i.p. |
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Applications |
A single intraperitoneal injection of 5 mg/kg UNC 0642 resulted in a plasma Cmax of 947 ng/mL and an AUC of 1265 h·ng/mL. However, UNC 0642 only displayed modest brain penetration, with a brain/plasma ratio of 0.33, which suggested that UNC 0642 might not be suitable for exploration of the role of G9a/GLP in the CNS. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. |
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Quality Control & MSDS
- View current batch:
Chemical structure
