XMD17-109
XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 μM, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 μM.
XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.[1]
Through intravenous injection and oral delivery of XMD17-109 in mice, the pharmacokinetic properties of this compound?are as bellows: the T1/2 (half time)?is 8.2?h, the plasma clearance is 8.64 mL/min/Kg (data of intravenous injection), the AUC (area under the curve) of oral delivery is 15745?h*ng/mL and the oral bioavailability is 90%.
Reference:
1. Deng, X., et al., Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry, 2013. 70: p. 758-767.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 638.8 |
| Cas No. | 1435488-37-1 |
| Formula | C36H46N8O3 |
| Synonyms | XMD17 109 |
| Solubility | ≥31.95 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(C2CCN(C(C3=CC(OCC)=C(NC4=NC=C5C(N(C6CCCC6)C(C=CC=C7)=C7C(N5C)=O)=N4)C=C3)=O)CC2)CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. | |||||
| Targets | ERK-5 | |||||
| IC50 | 4.2±0.69 μM(EC50, in HEK 293 cells) | |||||
Quality Control & MSDS
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