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2-Hydroxypropyl-β-cyclodextrin

Catalog No.
B6413
A cyclic oligosaccharide widely used to improve the aqueous solubility of a variety of compounds
Grouped product items
SizePriceStock Qty
1g
$50.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide containing 7 glucopyranose units, with an average of one hydroxypropyl group per unit. The circular arrangement of the glucose units forms a torus-shaped ring configuration, and CH2 groups and ether linkages of the molecule face the hollow interior of the configuration, which leads to a nonpolar cavity and a polar exterior. When a compound with appropriate geometry and 2-hydroxypropyl-β-cyclodextrin are in the same solution, the nonpolar aromatic parts of that compound tend to interact with the nonpolar interior of the 2-hydroxypropyl-β-cyclodextrin molecule. This complexation isolates the aromatic parts of that compound from the water, thereby increasing its aqueous solubility. 2-Hydroxypropyl-β-cyclodextrin has been widely used in improving the aqueous solubility of a variety of compounds, especially those containing a phenyl group, a group encompassing many drugs.?

References:

1.?Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. International Research Journal of Pharmacy, 2012, 3(1): 52-56.

2.?Shewale BD, Sapkal NP, Raut NA, et al. Effect of hydroxylpropyl-β-cyclodextrin on solubility of carvedilol. Indian Journal of Pharmaceutical Sciences, 2008, 70(2): 255-257.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt1541.55
Cas No.128446-35-5
FormulaC63H112O42
Solubility≥24.9 mg/mL in EtOH; ≥42 mg/mL in DMSO; ≥47 mg/mL in H2O
SDFDownload SDF
Canonical SMILESO[C@@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@H](O[C@@H]4[C@@H](O)[C@H](O)[C@H](O[C@@H]5[C@@H](O)[C@H](O)[C@H](O[C@@H]6[C@@H](O)[C@H](O)[C@H](O[C@@H]7[C@@H](O)[C@H](O)[C@H]8O[C@H]7COCC(O)C)O[C@H]6COCC(O)C)O[C@H]5COCC(C)O)O[C@H]4
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control