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- Naltrindole hydrochloride
Naltrindole hydrochloride
Naltrindole hydrochloride is a cell permeable, highly selective non-peptide δ opioid antagonist (Ki = 0.02 nM).?
In U266 cells, naltrexone treatment can significantly reduce the active phosphorylated form of kinases, and extracellular signaling regulates kinase and Akt levels, which may be related to its anti-proliferative activity[1].?
In mice, naltrindole (20 mg/kg, s.c) antagonizes the δ-selective agonist effect of enkephalin (DSLET), but does not prevent the anti-nociceptive effects of morphine or U50488H. Naltrexone is the only highly selective delta antagonist that is active when administered peripherally[2].?
References:
[1]. Mundra J J, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther, 2012, 342(2): 273-87.
[2]. Portoghese P S, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol, 1988, 146(1): 185-6.
Physical Appearance | A crystalline solid |
Storage | Store at RT |
M.Wt | 450.96 |
Cas No. | 111469-81-9 |
Formula | C26H26N2O3·HCl |
Solubility | Soluble in DMSO |
Chemical Name | (4bS,8R,8aR,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a-diol hydrochloride |
SDF | Download SDF |
Canonical SMILES | O[C@]([C@@H]1N(CC2CC2)CC3)(CC4=C5NC6=CC=CC=C46)[C@@]3(C7=C(C=C8)C1)[C@H]5OC7=C8O.Cl |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)