天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Toggle Nav
Close
  • Menu
  • Setting

Naltrindole hydrochloride

Catalog No.
B6429
δ opioid antagonist
Grouped product items
SizePriceStock Qty
5mg
$260.00
Ship with 10-15 days
10mg
$450.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Naltrindole hydrochloride is a cell permeable, highly selective non-peptide δ opioid antagonist (Ki = 0.02 nM).?

In U266 cells, naltrexone treatment can significantly reduce the active phosphorylated form of kinases, and extracellular signaling regulates kinase and Akt levels, which may be related to its anti-proliferative activity[1].?

In mice, naltrindole (20 mg/kg, s.c) antagonizes the δ-selective agonist effect of enkephalin (DSLET), but does not prevent the anti-nociceptive effects of morphine or U50488H. Naltrexone is the only highly selective delta antagonist that is active when administered peripherally[2].?

References:

[1]. Mundra J J, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther, 2012, 342(2): 273-87.

[2]. Portoghese P S, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol, 1988, 146(1): 185-6.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt450.96
Cas No.111469-81-9
FormulaC26H26N2O3·HCl
SolubilitySoluble in DMSO
Chemical Name(4bS,8R,8aR,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a-diol hydrochloride
SDFDownload SDF
Canonical SMILESO[C@]([C@@H]1N(CC2CC2)CC3)(CC4=C5NC6=CC=CC=C46)[C@@]3(C7=C(C=C8)C1)[C@H]5OC7=C8O.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Naltrindole hydrochloride