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Ruthenium Red

Catalog No.
B6740
Blocks Ca2+ uptake and release, and voltage-sensitive Ca2+ channels
Grouped product items
SizePriceStock Qty
100mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ruthenium red is a strong inhibitor of Ca2+ transport in mitochondrial, in erythrocyte membrane and in sarcoplasmic reticulum (SR) of rabbit skeletal muscle, with the Km of 4.5 μM and 2.0 mM for the two Ca2+-binding sites [1].

By kinetic experiments, there are two high-affinity Ca2+-binding sites face the cytoplasmic portion of the SR membranes, which are located in helical segments clustered in the transmembrane domain of Ca2+-ATPase, forming a Ca2+ channel.

SR vesicles were incubated with 10 μM-45Ca2+ and various ruthenium red concentrations for 15 min before being filtered for 45Ca counting. The titration curve of Ca2+ binding showed two well-differentiated saturating effects with the Km of 4.5 μM and 2.0 mM for the two Ca2+-binding sites. The ability of SR vesicles to bind Ca2+ was decreased by micromolar ruthenium red concentrations [1].

In the investigation of the ability of inhibiting caspsaicin-induced plasma extravasation in the rat trachea, ruthenium red can reduce the amount of plasma extravasation in dose-dependently, with a dose of 5 μmol/kg of completely inhibiting [2].

Reference:

[1] Corbalan-Garcia S, Teruel J A, Gomez-Fernandez J C. Characterization of Ruthenium Red-binding sites of the Ca2+-ATPase from sarcoplasmic reticulum and their interaction with Ca2+-binding sites [J]. Biochem J. 1992, 287(3): 767-774.

[2] Brokaw J J, White G W. Characterization of Ruthenium Red as an Inhibitor of Neurogenic Inflammation in the Rat Trachea [J]. Gen Pharmac. 1995, 26(2): 327-331.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt786.35
Cas No.11103-72-3
FormulaH42N14O2Ru3Cl6
Solubility≥7.86 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH
SDFDownload SDF
Canonical SMILES[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[O].[O].[Ru+2].[Ru+2].[Ru+2]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Related Biological Data

Ruthenium Red