* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference：
[1] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 10, p. 1015 - 1019
2
[ 68981-86-2 ]
[ 94015-05-1 ]
Reference：
[1] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 10, p. 1015 - 1019
3
[ 583-58-4 ]
[ 94015-05-1 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 7, p. 1501 - 1505
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 7, p. 1501 - 1505
4-Methyl-3-pyridinecarboxylic acid hydrochloride (1 : 1) (40 g, 230.4 mmol) was added to a refluxing mixture of sulphuric acid (20 mL) and MeOH (400 mL). The mixture was re fluxed overnight, then it was evaporated and the resulting slurry was added to a cold solution of NaHCOs (64 g) in water (360 mL). The product was extracted with DCM and the organic layer was dried over MgSC^, filtered and evaporated, yielding intermediate 1 (28.70 g, 83%).
83%
With sulfuric acid;Reflux;
Procedure a: 4-Methyl-3-pyridinecarboxylic acid hydrochloride (1 : 1) (40 g, 230.4 mmol) was added to a refluxing mixture of sulphuric acid (20 mL) and MeOH (400 mL). The mixture was refluxed overnight, then it was evaporated and the resulting slurry was added to a cold solution of NaHC03 (64 g) in water (360 mL). The product was extracted with DCM and the OL was dried over MgS04, filtered and evaporated, yielding intermediate 1 (28.70 g, 83%).
83%
With sulfuric acid;Reflux;
Procedure a: 4-Methyl-3-pyridinecarboxylic acid hydrochloride (1 : 1) (40 g, 230.4 mmol) was added to a refluxing mixture of sulphuric acid (20 mL) and MeOH (400 mL). The mixture was refluxed overnight, then it was evaporated and the resulting slurry was added to a cold solution of NaHC03 (64 g) in water (360 mL). The product was extracted with DCM and the OL was dried over MgS04, filtered and evaporated, yielding intermediate 1 (28.70 g, 83%).
83%
With sulfuric acid;Reflux;
4-Methyl-3-pyridinecarboxylic acid hydrochloride (1:1) (40 g, 230.4mmol) was added to a refluxing mixture of sulphuric acid (20 mL) and MeOH (400mL). The mixture was refluxed overnight, then it was evaporated and the resulting slurry was added to a cold solution of NaHCO3 (64 g) in water (360 mL). The product was extracted with DCM and the OL was dried over MgSO4, filtered and evaporated, yielding intermediate 1 (28.70 g, 83%).
83%
With sulfuric acid; In methanol;Reflux;
4-Methyl-3-pyridinecarboxylic acid hydrochloride (1:1) (40 g, 230.4 mmol) was added to a refluxing mixture of sulphuric acid (20 mL) and MeOH (400mL). The mixture was refluxed overnight, then it was evaporated and the resulting slurry was added to a cold solution of NaHCO3 (64 g) in water (360 mL). The product was extracted with DCM and the OL was dried over MgSO4, filtered and evaporated, yielding intermediate 21(28.70 g, 83%)
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