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[ CAS No. 93777-26-5 ] {[proInfo.proName]}

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Chemical Structure| 93777-26-5

Chemical Structure| 93777-26-5

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Quality Control of [ 93777-26-5 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Citations

Product Details of [ 93777-26-5 ]

CAS No. :	93777-26-5	MDL No. :	MFCD00070755
Formula :	C₇H₄BrFO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MMFGGDVQLQQQRX-UHFFFAOYSA-N
M.W :	203.01	Pubchem ID :	736327
Synonyms :		Chemical Name :	5-Bromo-2-fluorobenzaldehyde

Calculated chemistry of [ 93777-26-5 ] Expand+

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	39.49
TPSA :	17.07 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.58 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.82
Log Po/w (XLOGP3) :	2.76
Log Po/w (WLOGP) :	2.82
Log Po/w (MLOGP) :	2.63
Log Po/w (SILICOS-IT) :	3.08
Consensus Log Po/w :	2.62

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.22
Solubility :	0.124 mg/ml ; 0.000609 mol/l
Class :	Soluble
Log S (Ali) :	-2.77
Solubility :	0.342 mg/ml ; 0.00168 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.48
Solubility :	0.0668 mg/ml ; 0.000329 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.38

Safety of [ 93777-26-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 93777-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 93777-26-5 ]
Downstream synthetic route of [ 93777-26-5 ]

[ 93777-26-5 ] Synthesis Path-Upstream 1~2

1
[ 93777-26-5 ]
[ 446-52-6 ]
[ 374538-01-9 ]

Reference： [1] Tetrahedron, 2002, vol. 58, # 9, p. 1657 - 1666

2
[ 93777-26-5 ]
[ 911305-81-2 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 20, p. 6832 - 6846

[ 93777-26-5 ] Synthesis Path-Downstream 1~10

1
[ 544-92-3 ]
[ 93777-26-5 ]
[ 146137-79-3 ]

Reference： [1]Synthetic Communications,1997,vol. 27,p. 1199 - 1207

2
[ 6976-17-6 ]
[ 93777-26-5 ]
[ 329347-22-0 ]

Reference： [1]Tetrahedron Letters,2004,vol. 45,p. 9335 - 9339

3
[ 93777-26-5 ]
[ 445303-69-5 ]

Yield	Reaction Conditions	Operation in experiment
70%	With diethylamino-sulfur trifluoride; In dichloromethane;Heating / reflux;	5-Bromo-2-fluorobenzaldehyde (2 g, 9.8 mmol) in CH2Cl2 (50 ml) was treated at 0C. with (diethylamino)sulfur trifluoride (2 ml, 14.8 mmol). The reaction mixture was refluxed overnight and then quenched with saturated solution of NaHCO3. The aqueous phase was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed over silica gel (hexane-ethyl acetate 99 : 01) to provide 4-bromo-2-difluoromethyl-1-fluoro-benzene (1.55 g, 70%) as a colorless oil, MS: m/e=226.0 (M+H+).
61%	With diethylamino-sulfur trifluoride; In dichloromethane; at 20.0℃; for 18.0h;Inert atmosphere;	[143] To a solution of 5-bromo-2-fluoro-benzaldehyde (4.06 g, 20 mmol) in DCM (50 mL) was added DAST (diethylaminosulfur trifluoride) (4.03 g, 25 mmol) and the mixture was stirred at room temperature for 18 hours under nitrogen atmosphere. The reaction mixture was quenched into ice-water and extracted with DCM. The organic layer was dried and concentrated. Yield: 2.74 g (61 %)
	With diethylamino-sulfur trifluoride; In dichloromethane; at 20.0℃; for 1.0h;	Preparation 3:4-BROMO-2-(DIFLUOROMETHYL)-l-FLUOROBENZENE5-bromo-2-fluorobenzaldehyde (2.0 g, 9.85 mmol) and diethylaminosulfur trifluo?de (2.2 ml) was stirred at ambient temperature for 1 hour. Methylene chloride (100 ml) was added and the solution was cooled to 0 0C. Aqueous sodium bicarbonate (10%, 50 ml) was added slowly and the phases were separated. The organic phase was washed with water (50 ml), dried (MgSO4), filtered and evaporated to dryness to yield the crude product (1.79 g). MS m/z (rel. intensity, 70 eV) 226 (M+, 98), 224 (M+, bp), 207 (17), 145 (79), 125 (22).

Reference： [1]Patent: US2003/229096,2003,A1 .Location in patent: Page 20; 7
[2]Patent: WO2016/25918,2016,A1 .Location in patent: Paragraph 143
[3]Patent: WO2007/65655,2007,A1 .Location in patent: Page/Page column 28

4
[ 93777-26-5 ]
[ 146137-79-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; iron(III) chloride; In water; N,N-dimethyl-formamide;	Step A 5-Cyano-2-fluorobenzaldehyde To a solution of 5-bromo-2-fluorobenzaldehyde (1.93 g, 9.51 mmol) in DMF (4 mL) was added copper(I) cyanide (0.98 g, 10.93 mmol). The mixture was heated to 190 ° C. and stirred for 5 h. The dark brown reaction mixture was poured into a solution containing ferric chloride (3.0 g), conc. HCl (0.93 mL) and water (6 mL) and warmed to 65 ° C. for 20 min. The mixture was partitioned between toluene (20 mL) and water (20 mL). The organic was washed with diluted HCl (25 mL), water (20 mL), 10percent sodium hydroxide (25 mL), dried over magnesium sulfate, and concentrated to provide a solid product: 1H NMR (CDCl3) delta 10.34 (m, 1H), 8.21 (m, 1H), 7.90 (m, 1H), 7.35 (m, 1H).
	With hydrogenchloride; iron(III) chloride; In water; N,N-dimethyl-formamide;	Step A 5-Cyano-2-fluorobenzaldehyde To a solution of 5-bromo-2-fluorobenzaldehyde (1.93 g, 9.51 mmol) in DMF (4 mL) was added copper(I) cyanide (0.98 g, 10.93 mmol). The mixture was heated to 190° C. and stirred for 5 h. The dark brown reaction mixture was poured into a solution containing ferric chloride (3.0 g), conc. HCl (0.93 mL) and water (6 mL) and warmed to 65° C. for 20 min. The mixture was partitioned between toluene (20 mL) and water (20 mL). The organic was washed with diluted HCl (25 mL), water (20 mL), 10percent sodium hydroxide (25 mL), dried over magnesium sulfate, and concentrated to provide a solid product: 1H NMR (CDCl3) delta 10.34 (m, 1H), 8.21 (m, 1H), 7.90 (m, 1H), 7.35 (m, 1H).

Reference： [1]Patent: US6376499,2002,B1
[2]Patent: US6610692,2003,B1

5
[ 14221-01-3 ]
[ 93777-26-5 ]
[ 146137-79-3 ]

Yield	Reaction Conditions	Operation in experiment
	In N-methyl-acetamide;	PREPARATION 88(1) To a solution of 5-bromo-2-fluorobenzaldehyde (10 g) in dimethylformamide (60 mL) were added zinc cyanide (6.92 g) and tetrakis(triphenylphosphine)palladium(O) (2.28 g), and the mixture was stirred at 80° C. for 6 hours. The resulting mixture was diluted with ethyl acetate and washed successively with water and brine. The organic layer was dried over sodium sulfate and evaporated in vacuo. The residue was subjected to a silica gel column chromatography eluding with a mixture of hexane and ethyl acetate (3:1) to give 5-cyano-2-fluorobenzaldehyde (5.3 g) as a solid substance. NMR (DMSO-d6, delta): 7.35 (1H, t, J=9 Hz), 7.91 (1H, m), 8.22 (1H, dd, J=2, 7 Hz), 10.36 (1H, s); Mass m/z: 150 (M++1).

Reference： [1]Patent: US6384080,2002,B1

6
[ 144-55-8 ]
[ 93777-26-5 ]
[ 445303-69-5 ]

Yield	Reaction Conditions	Operation in experiment
70%	With diethylaminosulfur trifluoride; In dichloromethane;	4-Bromo-2-difluoromethyl-1-fluoro-benzene 5-Bromo-2-fluorobenzaldehyde (2 g, 9.85 mmol) was dissolved in CH2Cl2 (50 ml). The reaction mixture was put under an argon atmosphere and cooled to 0 C. Diethylaminosulfur trifluoride (2.04 ml, 14.78 mmol) was added dropwise. The mixture was allowed to warm up to room temperature and stirred overnight. It was then quenched with a saturated aqueous NaHCO3 solution. The layers were separated and the aqueous one was extracted with CH2Cl2. The combined organic phases were dried with Na2SO4 and the solvent evaporated. The brown oil was chromatographed (silica, elution hexane/AcOEt) to afford the title compound (1.55 g, 70%) as a colorless oil. MS: m/e=226.0 (M+H+).

Reference： [1]Patent: US2002/151715,2002,A1

7
[ 108-20-3 ]
[ 6976-17-6 ]
[ 93777-26-5 ]
[ 329347-22-0 ]

Yield	Reaction Conditions	Operation in experiment
86%	With hydrogenchloride; sodium carbonate; In hexane; water; dimethyl sulfoxide;	Example 1 Synthesis of 4-(4-bromo-2-formyl-N-methylanilino)-butyric acid To a suspension of 5-bromo-2-fluorobenzaldehyde (20.3 g) and <strong>[6976-17-6]4-methylaminobutyric acid hydrochloride</strong> (18.4 g) in DMSO/water(100 ml/100 ml) was slowly add sodium carbonate (25.4 g), followed by stirring at 105°C to 110°C for 3.5 hours. The mixture was cooled to 50°C to 60°C, atwhich temperature 6N hydrochloric acid was added dropwise to adjust the pH to 3. The mixture was extracted with ethyl acetate (200 ml + 100 ml), and the organic layer was washed with a saturated aqueous sodium chloride solution (40 ml * 2) and water (40ml). The organic layer was concentrated, and the concentrate was then dissolved in IPE (50 ml), to which n-hexane (50 ml) was added dropwise. The precipitates were filtered out and washed with IPE/n-hexane (16 ml/4 ml). The filter cake was dried under reduced pressure at room temperature for 4 hours to give 4-(4-bromo-2-formyl-N-methylanilino)butyric acid (25.9 g, 86percent yield) as yellow crystals. 1H-NMR (CDCl3, delta, 300 MHz): 1.95 (2H, tt, J = 6.5, 7.4 Hz), 2.38 (2H, t, J = 6.5 Hz), 2.88 (3H, s), 3.17 (2H, t, J = 7.4 Hz), 7.01 (1H, d, J = 8.7 Hz), 7.55 (1H, dd, J = 8.7, 2.5 Hz), 7.87 (1H, d, J = 2.5 Hz), 10.16 (1H, s).

Reference： [1]Patent: EP1211239,2002,A1

8
[ 93777-26-5 ]
[ 465529-56-0 ]

Reference： [1]Patent: WO2011/18454,2011,A1
[2]Patent: WO2011/20861,2011,A1
[3]Patent: EP3269715,2018,A1
[4]Patent: US2019/194168,2019,A1

9
copper(l) cyanide [ No CAS ]
[ 93777-26-5 ]
[ 146137-79-3 ]

Yield	Reaction Conditions	Operation in experiment
60%	In N,N-dimethyl-formamide;Reflux;	A mixture of 74 (1.82 g, 9 mmol) and copper (I) cyanide (1.4 g, 15.7 mmol) in DMF (14.0 mL) was stirred at reflux overnight. After completion, the reaction mixture was cooled to rt and poured into a solution of water (10 mL) and NH4OH (10 ml) followed by extraction with EtOAc (3 x 25 mL). The organic layer was sequentially washed with brine (2 x 15 mL), dried over anhydrous Na2S04, and concentrated in vacuo to give 757a (0.80 g, 60 percent).

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 8582 - 8591
[2]Patent: WO2013/56003,2013,A2 .Location in patent: Page/Page column 63

10
[ 865139-18-0 ]
[ 93777-26-5 ]
4'-(benzyloxy)-4-fluoro-2',6'-dimethylbiphenyl-3-carbaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58.4%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; In 1,2-dimethoxyethane; water; toluene; at 100 - 120℃; for 2.5h;Microwave irradiation;	4-(Benzyloxy)-2,6-dimethylphenyl)boronic acid 12b (256 mg, 1 mmol), 2-fluoro-5-bromo-benzaldehyde (203 mg, 1 mmol), 2 M aqueous sodium carbonate solution (1 mL, 2 mmol), 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (37 mg, 0.08 mmol) and tris(dibenzylideneacetone)dipalladium (18 mg, 0.02 mmol) were dissolved in 3 mL of the mixture solvent of ethylene glycol dimethyl ether and toluene (V/V = 1:2). The reaction mixture was heated at 100 C for 2 hours, and then at 120C for 0.5 hours under micarowave condition. The resulting mixture was added with 10 mL of water and extracted with ethyl acetate (10 mL*3). The combined organic extracts were washed with saturated sodium chloride solution (30 mL), dried with anhydrous magnesium sulphate and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with elution system B to obtain the title compound 4'-(benzyloxy)-4-fluoro-2',6'-dimethylbiphenyl-3-carbaldehyde 18a (390 mg, yield 58.4%) as a colorless oil. MS m/z (ESI): 335.2 [M+1]
58.4%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; In 1,2-dimethoxyethane; water; toluene; at 100 - 150℃; for 2.5h;Microwave irradiation; Inert atmosphere;	(4-(Benzyloxy)-2,6-dimethylphenyl)boronic acid 12b (256 mg, 1 mmol), 2-fluoro-5-bromo-benzaldehyde (203 mg, 1 mmol), 2M aqueous sodium carbonate solution (1 mL, 2 mmol), 2-dicyclohexylphosphino-2?,6?-dimethoxybiphenyl (37 mg, 0.08 mmol) and tris(dibenzylideneacetone)dipalladium (18 mg, 0.02 mmol) were dissolved in 3 mL of a mixture of the solvents ethylene glycol dimethyl ether and toluene (V/V=1:2). The reaction mixture was heated at 100 C. for 2 hours, and then at 120 C. for 0.5 hours under microwave conditions. The resulting mixture was mixed with 10 mL of water and extracted with ethyl acetate (10 mL×3). The combined organic extracts were washed with saturated sodium chloride solution (30 mL), dried with anhydrous magnesium sulphate, and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with elution system B to obtain the title compound 4?-(benzyloxy)-4-fluoro-2?,6?-dimethylbiphenyl-3-carbaldehyde 18a (390 mg, yield 58.4%) as a colorless slime. MS m/z (ESI): 335.2 [M+1]

Reference： [1]Patent: EP2803664,2014,A1 .Location in patent: Paragraph 0189; 0190
[2]Patent: US2015/5282,2015,A1 .Location in patent: Paragraph 0293; 0294; 0295

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Technical Information

? Alkyl Halide Occurrence ? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Bucherer-Bergs Reaction ? Clemmensen Reduction ? Complex Metal Hydride Reductions ? Corey-Chaykovsky Reaction ? Corey-Fuchs Reaction ? Fischer Indole Synthesis ? Friedel-Crafts Reaction ? General Reactivity ? Grignard Reaction ? Hantzsch Dihydropyridine Synthesis ? Henry Nitroaldol Reaction ? Hiyama Cross-Coupling Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Julia-Kocienski Olefination ? Kinetics of Alkyl Halides ? Knoevenagel Condensation ? Kumada Cross-Coupling Reaction ? Leuckart-Wallach Reaction ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Mukaiyama Aldol Reaction ? Nozaki-Hiyama-Kishi Reaction ? Passerini Reaction ? Paternò-Büchi Reaction ? Petasis Reaction ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Prins Reaction ? Reactions of Aldehydes and Ketones ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Reactions of Benzene and Substituted Benzenes ? Reactions of Dihalides ? Reformatsky Reaction ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Stetter Reaction ? Stille Coupling ? Stobbe Condensation ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling ? Tebbe Olefination ? Ugi Reaction ? Vilsmeier-Haack Reaction ? Wittig Reaction ? Wolff-Kishner Reduction

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[ 93777-26-5 ]

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[ 95-15-8 ]

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[ 13096-62-3 ]

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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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